个人介绍文字

2003年师从赵进东院士于北京大学生命科学学院获得生物科学学士学位，2004年至2009年师从诺贝尔奖得主Michael Brown和Joseph Goldstein教授于美国得克萨斯大学西南医学中心获得生物医学博士学位，2009年至2015年师从Marc Tessier-Lavigne教授先后在美国基因泰克公司和洛克菲勒大学从事博士后研究，2015年入职北京大学生命科学学院担任博士生导师。

教育经历

2004-2009，理学博士，美国得克萨斯大学西南医学中心
1999-2003，理学学士，北京大学生命科学学院

工作经历

2024-至今，名誉教授，北京协和医院
2023-至今，双聘教授，北京大学第三医院
2022-至今，博雅特聘教授，北京大学
2020-2023，合作研究员，北京脑科学与类脑研究中心
2019-2024，合作研究员，深圳湾实验室
2017-2022，博雅青年学者，北京大学
2015-至今，研究员，北京大学麦戈文脑科学研究所
2015-至今，研究员，北京大学生命科学联合中心
2015-至今，博士生导师，北京大学生命科学学院
2011-2015，博士后，美国洛克菲勒大学（The Rockefeller University）
2009-2011，博士后，美国基因泰克公司（Genentech Inc.）

荣誉奖励

2021，中国神经科学重大进展
2020，北京大学优秀博士论文指导教师
2018，北京大学优秀班主任
2016，“求是”杰出青年学者奖
2015，Tri-Institutional Breakout Prize

科研领域描述

团队整合人类临床样本、动物疾病模型、先进成像技术、多组学分析等跨学科手段，致力于生物医学的前沿交叉方向，探索神经系统、免疫系统、代谢系统等的互作调控，在分子、细胞、器官、机体等不同层面开拓肿瘤神经生物学（cancer neuroscience）、神经免疫（neuroimmunology）、免疫代谢（immunometabolism）的创新概念和视角，验证肿瘤、代谢疾病、神经退行性疾病等重大人类疾病的全新治疗策略和药物靶点。获得国家杰出青年科学基金、优秀青年科学基金、高层次青年人才项目、原创探索计划项目、重大专项项目、重点研发计划项目等支持，并与临床医院和生物制药产业建立深入合作。主要研究方向包括：
1. 肿瘤的神经免疫互作；
2. 代谢疾病及并发症；
3. 免疫紊乱和自免疫疾病；
4. 神经退行性疾病和神经炎症。

代表性论文

Publications since the current position:
1. Representative Publications (# corresponding author):
(1) Zhao Y, Huang Y, Deng Z, Cao Y#, Yang J#. Inflammatory Signatures of Microglia in Hypercortisolemia-Related Depression. Cell Insight. 2025 Apr;4(2):100222.
(2) Zhao J, Wu D, Liu J, Zhang Y, Li C, Zhao W, Cao P, Wu S, Li M, Li W, Liu Y, Huang Y, Cao Y, Sun Y, Yang E, Ji N#, Yang J#, Chen J#. Disease-Specific Suppressive Granulocytes Participate in Glioma Progression. Cell Reports. 2024 Dec;43(12):115014.
(3) Zhao Y, Huang Y, Cao Y, Yang J#. Astrocyte-Mediated Neuroinflammation in Neurological Conditions. Biomolecules. 2024 Sep;14(10):1204.
(4) Gong X, Zhuang J, Chong K, Xu Q, Ling X, Cao L, Wu M#, Yang J#, Liu B#. Far-Red Aggregation-Induced Emission Hydrogel-Reinforced Tissue Clearing for 3D Vasculature Imaging of Whole Lung and Whole Tumor. Advanced Materials. 2024 Aug;36(35):2402853.
(5) Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai CH, Zhou X, Hu H, Fu W, Chen J, Yang J#. Multiple Cancer Cell Types Release LIF and Gal3 to Hijack Neural Signals. Cell Research. 2024 May;34(5):345-354.
(6) Gong X, Chong K, Liu J, Cheng W, Yang J#, Liu B#. AIENP-Reinforced DISCO Method for Whole-Tissue Three-Dimensional Reconstruction of Pulmonary Capillaries. Advanced Functional Materials. 2024 Mar;34(13):2312176.
(7) Zhang M, Liu T, Yang J#. Skin neuropathy and immunomodulation in diseases. Fundamental Research. 2024 Mar;4(2):218-225.
(8) Liu J, Li Z, Li M, Du W, Baumeister W, Yang J#, Guo Q#. Vimentin regulates nuclear segmentation in neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 2023 Nov 28;120(48):e2307389120.
(9) Liu T, Liu J, Chen H, Zhou X, Fu W, Cao Y, Yang J#. Cannabinoid receptor 2 signal promotes type 2 immunity in the lung. Cell Insight. 2023 Oct 6;2(5):100124.
(10) Cao Y, Chen H, Yang J#. Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies. European Journal of Immunology. 2023 Oct;53(10):e2250136.
(11) Cao Y, Liu T, Zhou X, Fu W, Li J, Yang J#. 3D anatomy of autonomic innervations in immune organs of a non-human primate and the human. Fundamental Research. 2023 Mar;3(2):249-256.
(12) Yang J#, Yaron A, Liu K. Editorial: Neuroimmune interactions in peripheral neuropathy. Frontiers in Molecular Neuroscience. 2022 May;15:929081.
(13) Liu C, Yang J#. Enteric glial cells in immunological disorders of the gut. Frontiers in Cellular Neuroscience. 2022 Apr;16:895871.
(14) Cao Y, Wang Y, Yang J#. NAD+-dependent mechanism of pathological axon degeneration. Cell Insight. 2022 Apr;1(2):100019.
(15) Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J#. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. Protein Cell. 2021 Aug;12(8):621-638.
(16) Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J#. Metabolic stress drives sympathetic neuropathy within the liver. Cell Metabolism. 2021 Mar 2;33(3):666-675.e4.
(17) Jiang Y, Liu T, Lee CH, Chang Q, Yang J#, Zhang Z#. The NAD(+)-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature. 2020 Dec;588(7839):658-663.
(18) Liu T, Yang L, Han X, Ding X, Li J, Yang J#. Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.
(19) Wang Q, Liu K, Yang L, Wang H, Yang J#. BoneClear: whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.
(20) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J#. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.e3.
(21) Zhou N, Liu K, Sun Y, Cao Y, Yang J#. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein Cell. 2019 Feb;10(2):87-103.
(22) Zhou N, Yang J#. Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250.

2. Additional Publications:
(1) Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, Simon DJ. An axon-T cell feedback loop enhances inflammation and axon degeneration. Cell Reports. 2024 Feb 27;43(2):113721.
(2) Yang L, Wang X, Yu XX, Yang L, Zhou BC, Yang J, Xu CR. The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms. Developmental Cell. 2023 Sep 25;58(18):1688-1700.e6.
(3) Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z. Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discovery. 2022 Dec 28;8(1):141.
(4) Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z. Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8. Nature Communications. 2022 Aug 25;13(1):4988.
(5) Hu H, Cui YW, Yang J, Cao Y. Loss of the sympathetic signal produces sterile inflammation of the prostate. Frontiers in Molecular Neuroscience. 2022 May;15:855376.
(6) Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature Neuroscience. 2022 May;25(5):577-587.
(7) Qian K, Liu J, Cao Y, Yang J, Qiu S. Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice. Molecular Brain. 2021 Apr 19;14(1):71.
(8) Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K(+) channel regulates Parkinson`s pathology. Nature. 2021 Mar;591(7850):431-437.
(9) Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in ε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice. Neuroscience Bulletin. 2021 Mar;37(3):311-322.
(10) Simon DJ, Pitts J, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tešić Mark M, Molina H, Tessier-Lavigne M. Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. Cell. 2016 Feb 25;164(5):1031-45.

3. Book Chapters:
(1) Cao Y, Yang J. Mechanisms of Pathological Axonal Degeneration. In: Tran T.S. and Yaron A.(eds) Wiring the Nervous System, 2024 Jan;215-250. River Publishers, Gistrup, Denmark.
(2) Cao Y, Yang J. Whole-Tissue Immunolabeling and 3D Fluorescence Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E.(eds) Methods in Molecular Biology, 2020 Jun 11;2143:223-232. Humana, New York, NY.
(3) Wang F, Yang J, He Z. Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E.(eds) Comprehensive Developmental Neuroscience (2nd Edition), 2020 Jun 5;217-230. Academic Press, Cambridge, MA.

Publications before the current position:
(1) Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.
(2) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.
(3) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89. (* contributed equally)
(4) Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10):4039-44.
(5) Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O`Leary DD, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. Journal of Neuroscience. 2012 Dec 5;32(49):17540-53.
(6) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.
(7) Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. American Journal of Physiology-Endocrinology and Metabolism. 2009 Jul;297(1):E134-41. (* contributed equally)
(8) Yang J*, Zhao TJ*, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 5;105(31):10750-5. (* contributed equally)
(9) Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.
(10) Yang J, Dong C, Huang X, Zhao J. Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from DNA digestion solutions. Analytical Biochemistry. 2003 Nov 1;322(1):99-103.

执教课程

春季学期（第二学期）：
《免疫学》，本科课程，34学时
《神经病理学》，本科课程，34学时

实验室简介