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个人简历
教育经历
1999-2005, 理学博士, 生命科学, 北京大学
1995-1999, 理学学士, 生命科学, 北京大学
1995-1999, 理学学士, 生命科学, 北京大学
工作经历
2011 - 至今 , 研究员 , 北京大学，生命科学学院
2010 - 2011 , 博士后 , 美国范德堡大学（Vanderbilt University）
2005 - 2010 , 博士后 , 美国国立卫生研究院（National Institutes of Health，NIH ）
2010 - 2011 , 博士后 , 美国范德堡大学（Vanderbilt University）
2005 - 2010 , 博士后 , 美国国立卫生研究院（National Institutes of Health，NIH ）
代表性论文
1. Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R#, Xu D#. Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem. 2016 Sep 6. pii: jbc.C116.747758. (# co-corresponding author)
2. Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D*. (2015) Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun. Feb 11; 6:6233.
3. Xu D.*, Shen W.*, Guo R., Xue Y., Yang J., Sharov A., Srikantan S., Yang J., Fox D., Peng W., Qian Y., Martindale J., Piao Y., Machamer J., Joshi S., Mohanty S., Shaw A., Lloyd T., Brown G., Ko M., Gorospe M., Zou S., Wang W. (2013) Top3β is an RNA topoisomerase that interacts with Fragile X syndrome protein to promote synapse formation. Nature Neuroscience , 16:1238–1247
4. Yan Z*, Guo R*, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP,Li L, Seidman MM, Wang W. (2012) A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell. July 13; 47(1): 61–75 (*co-1st author)
5. Wang, F., Yang, Y., Singh, T.R., Busygina, V., Guo, R., Wan, K., Wang, W., Sung, P., Meetei, A.R., and Lei, M. (2010) Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure. 2010 Sep 8;18(9):1159-70.
6. Xu, D., Muniandy, P., Leo ,E., Yin, J., Thangavel, S., Shen, X., Ii, M., Agama, K., Guo, R., etc (2010) Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J. Sep 15;29(18):3140-55
7. Islam, M.N., Fox, D. 3rd, Guo, R., Enomoto, T., and Wang, W. (2010) RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol. May;30(10):2460-72
8. Guo, R.*, Xu, D.*, and Wang, W. (2008) Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome. Methods. Review (* co-first authors)
9. Xu, D.*, Guo, R.*, Sobeck, A., Bachrati, C.Z., Yang, J., Enomoto, T., Brown, G.W., Hoatlin, M.E., Hickson, I.D., and Wang, W. (2008) RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev. Oct 15; 22(20):2843-55. (* co-first authors)
(Highlighted by News & Views, Nature 456:453-454, 2008; a Perspective, Genes & Dev. 22:2737-2742. 2008; Nature Rev. Mol. Cell. Biol. 9:920, 2008).
10. Xue, Y., Li, Y., Guo, R., Ling, C., and Wang W. (2008) FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. Hum Mol Genet. Jun 1; 17(11):1641-52.
11. Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., and Nussenzweig, A. (2006) Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. Sep 14; 443(7108):222-5.
12. Guo, R., Xue, H., Huo, X., Xu, D., Hu, J., and Huang, L. (2006) Ssh10b2 differs from its paralogue Ssh10b in cellular abundance and the ability to constrain DNA supercoils. Wei Sheng Wu Xue Bao. Apr; 46(2):323-7. (in Chinese)
13. Guo, R., Xue, H., and Huang, L. (2003) Ssh10b, a conserved thermophilic archaeal protein, binds RNA in vivo. Mol Microbiol. Dec; 50(5): 1605-15.
2. Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D*. (2015) Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun. Feb 11; 6:6233.
3. Xu D.*, Shen W.*, Guo R., Xue Y., Yang J., Sharov A., Srikantan S., Yang J., Fox D., Peng W., Qian Y., Martindale J., Piao Y., Machamer J., Joshi S., Mohanty S., Shaw A., Lloyd T., Brown G., Ko M., Gorospe M., Zou S., Wang W. (2013) Top3β is an RNA topoisomerase that interacts with Fragile X syndrome protein to promote synapse formation. Nature Neuroscience , 16:1238–1247
4. Yan Z*, Guo R*, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP,Li L, Seidman MM, Wang W. (2012) A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell. July 13; 47(1): 61–75 (*co-1st author)
5. Wang, F., Yang, Y., Singh, T.R., Busygina, V., Guo, R., Wan, K., Wang, W., Sung, P., Meetei, A.R., and Lei, M. (2010) Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure. 2010 Sep 8;18(9):1159-70.
6. Xu, D., Muniandy, P., Leo ,E., Yin, J., Thangavel, S., Shen, X., Ii, M., Agama, K., Guo, R., etc (2010) Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J. Sep 15;29(18):3140-55
7. Islam, M.N., Fox, D. 3rd, Guo, R., Enomoto, T., and Wang, W. (2010) RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol. May;30(10):2460-72
8. Guo, R.*, Xu, D.*, and Wang, W. (2008) Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome. Methods. Review (* co-first authors)
9. Xu, D.*, Guo, R.*, Sobeck, A., Bachrati, C.Z., Yang, J., Enomoto, T., Brown, G.W., Hoatlin, M.E., Hickson, I.D., and Wang, W. (2008) RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev. Oct 15; 22(20):2843-55. (* co-first authors)
(Highlighted by News & Views, Nature 456:453-454, 2008; a Perspective, Genes & Dev. 22:2737-2742. 2008; Nature Rev. Mol. Cell. Biol. 9:920, 2008).
10. Xue, Y., Li, Y., Guo, R., Ling, C., and Wang W. (2008) FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. Hum Mol Genet. Jun 1; 17(11):1641-52.
11. Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., and Nussenzweig, A. (2006) Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. Sep 14; 443(7108):222-5.
12. Guo, R., Xue, H., Huo, X., Xu, D., Hu, J., and Huang, L. (2006) Ssh10b2 differs from its paralogue Ssh10b in cellular abundance and the ability to constrain DNA supercoils. Wei Sheng Wu Xue Bao. Apr; 46(2):323-7. (in Chinese)
13. Guo, R., Xue, H., and Huang, L. (2003) Ssh10b, a conserved thermophilic archaeal protein, binds RNA in vivo. Mol Microbiol. Dec; 50(5): 1605-15.
