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个人简历
教育经历
2003 - 2008 , 理学博士 , 密歇根大学
1998 - 2002 , 理学学士 , 北京大学
1998 - 2002 , 理学学士 , 北京大学
工作经历
2020-至今 , 长聘副教授, 北京大学
2014-至今 , 研究员/独立PI, 北京大学
2014 - 2019 , 助理教授, 北京大学
2011 - 2013 , 项目科学家, 加州大学圣地亚哥分校
2009 - 2011 , 博士后, 加州大学圣地亚哥分校（导师：Jack Dixon）
2014-至今 , 研究员/独立PI, 北京大学
2014 - 2019 , 助理教授, 北京大学
2011 - 2013 , 项目科学家, 加州大学圣地亚哥分校
2009 - 2011 , 博士后, 加州大学圣地亚哥分校（导师：Jack Dixon）
科研领域描述
1. Kinases
2. Immunoglobulins
3. Structural biology
2. Immunoglobulins
3. Structural biology
代表性论文
1. Du, S., Cao, Y., Zhu, Q., Yu, P., Qi. F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., Liu, J., Nie, J., Zheng, Y., Liang, H., Liu, R., Gong, S., Xu, H., Yisimayi, A., Lv, Q., Wang, B., He, R., Han, Y., Zhao, W., Bai, Y., Qu, Y., Gao, X., Ji, C., Wang, Q., Gao, N., Huang, W., Wang, Y., Xie, S.X*., Su, X.-d*., Xiao, J.*, Qin, C.* (2020). Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 183:1013-1023.e13.
2. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020). Structural insights into immunoglobulin M. Science 367:1014-1017.
3. Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research 30:602-609.
4. Ji, C., Du, S., Li, P., Zhu, Q., Yang, X., Long, C., Yu, J., Shao, F.*, Xiao, J.* (2019). Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8. PLoS Pathog. 15:e1007876.
5. Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044.
6. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.
7. Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H.D.T., Svergun, D.I., Xiao, J.*, Zhang, Y.*, Wang, J.H.*, Meijers, R*. (2018). Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron. 97(6):1261-1267.
8. Sun, X., Li, Y., He, W., Ji, C., Xia, P., Wang, Y., Du, S., Li, H., Raikhel, N., Xiao, J.*, Guo, H.* (2017). Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:15758.
9. Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990.
10. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238.
2. Li, Y., Wang, G., Li, N., Wang, Y., Zhu, Q., Chu, H., Wu, W., Tan, Y., Yu, F., Su, X.D., Gao, N., Xiao, J.* (2020). Structural insights into immunoglobulin M. Science 367:1014-1017.
3. Wang, Y., Wang, G., Li, Y., Zhu, Q., Shen, H., Gao, N., Xiao, J.* (2020). Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Research 30:602-609.
4. Ji, C., Du, S., Li, P., Zhu, Q., Yang, X., Long, C., Yu, J., Shao, F.*, Xiao, J.* (2019). Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8. PLoS Pathog. 15:e1007876.
5. Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044.
6. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.
7. Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H.D.T., Svergun, D.I., Xiao, J.*, Zhang, Y.*, Wang, J.H.*, Meijers, R*. (2018). Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron. 97(6):1261-1267.
8. Sun, X., Li, Y., He, W., Ji, C., Xia, P., Wang, Y., Du, S., Li, H., Raikhel, N., Xiao, J.*, Guo, H.* (2017). Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:15758.
9. Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990.
10. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238.
执教课程
生物化学（本科，主讲）
