时间：2018年12月27日（星期四）13:00-14:00
地点：金光生命科学大楼411
讲座人：Xin Liu, Ph.D.
Postdoctoral research fellow, University of Texas Southwestern Medical Center

题目：Decoding Regulatory Mechanisms of Hematopoiesis

摘要：Hematopoiesis requires highly coordinated gene expression through transcriptional and post-transcriptional mechanisms. By comparing enhancer landscape, transcriptional factor occupancy, 3D chromatin structure and transcriptomic changes during blood cell differentiation, I identified lineage-specific enhancers and macro-molecular interactions driving enhancer activation, providing initial insights into enhancer dynamics and gene expression programs directing lineage-specific transcription during hematopoiesis. Further comparison between the proteomic and transcriptomic changes in erythroid development uncovered post-transcriptional pathways leading to enhanced mitochondrial biogenesis. Perturbation of mitochondria interrupted intracellular metabolism, leading to altered transcriptional regulation and defective lineage differentiation, which provide a new pathway between mitochondrial biogenesis and epigenetic gene regulation indispensable for normal erythropoiesis.

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