生命科学学院学术报告
题目：Plasticity of alternative splicing determines cancer stem cell phenotypes
报告人：Chonghui Cheng, M.D., Ph.D.
Associate Professor
Baylor College of Medicine,
Department of Molecular and Human Genetics
Lester & Sue Smith Breast Center
时间：2016年6月22日（星期三）15:30-16:30
地点：生命科学学院208会议室
主持人：伊成器
Working at the interface of RNA splicing and breast cancer biology, our research focus is on regulation of breast cancer metastasis driven by alternative splicing. We use molecular biology and bioinformatics approaches in conjunction with genetic models and patient samples to discover rules and networks that regulate breast cancer metastasis and associated processes. Our work provided a conceptual framework implicating that RNA alternative splicing serves as a causal mechanism driving Epithelial-Mesenchymal Transition and breast cancer progression. We also discovered a novel splicing-mediated pathway that promotes cancer metastasis. We demonstrated that the RNA binding protein hnRNPM reprograms alternative splicing and drives a breast cancer metastatic phenotype. We are now testing the hypothesis that the plasticity of alternative splicing determines cancer stem cell phenotypes.
欢迎各位老师同学积极参加！