北京大学 | ENGLISH
讲座信息
Lipid storage and trafficking in human metabolic and neurodegenerative disorders
发布时间:2015-12-01      点击量:1278
主讲人:Hongyuan Yang
讲座地点:北京大学生命科学学院邓祐才报告厅
讲座日期:2015-12-07
讲座时间:14:00 — 15:00
联系人: 陈晓伟 (Tel. 6276-8919)
 

IMM & CLS Research Seminar

Title:Lipid storage and trafficking in human metabolic and neurodegenerative disorders

Speaker:Hongyuan Yang, Ph.D.

Professor and NHMRC Senior Research Fellow

School of Biotechnology and Biomolecular Sciences

The University of New South Wales, Australia

Time:2015年12月7日(星期一)下午2:00-3:00

Place:北京大学生命科学学院邓祐才报告厅

Host:北京大学分子医学研究所  陈晓伟 (Tel. 6276-8919)

Abstract:

Obesity is characterized by accumulation of adipocytes loaded with lipid droplets (LDs). We have recently identified a number of yeast gene products that regulate the size and number of LDs. Notably, deletion of a previously uncharacterized gene, FLD1, results in the formation of “super-sized” LDs. The human orthologue of Fld1p is SEIPIN, and loss-of-function mutations of the SEIPIN gene are associated with human Berardinelli-Seip Congenital Lipodystrophy 2 (BSCL2). We use mouse and fly models to confirm an essential role of SEIPIN in adipogenesis. Therefore, SEIPIN regulates both systemic (adipocyte differentiation) and cellular (LD formation) lipid storage. Our recent results suggest that SEIPIN functions in the metabolism of phospholipids, and that SEIPIN deficiency causes accumulation of certain lipid species, such as phosphatidic acid. These accumulated lipids may interfere with PPARgamma function during adipocyte differentiation in preadipocytes, and may also cause morphological changes of LDs in other cell types.

Sterols as essential components of eukaryotic membranes must be sorted precisely and transported efficiently. Abnormal subcellular distribution of cholesterol is associated with heart and neurodegenerative diseases including Alzheimer’s disease and Niemann Pick C disease, which is characterized by cholesterol accumulation in endosomes and lysosomes. The intracellular trafficking of cholesterol remains a challenging subject in cell biology. We have recently identified novel cytosolic proteins essential for cholesterol efflux from late endosomes and lysosomes, including ORP5, Hrs/Vps27 and Vps4.

欢迎各位老师同学积极参加!

[友情链接]
北大生科微信公众号 生声不息微信公众号
联系我们 | 地理位置
北京大学生命科学学院 版权所有 地址:北京市海淀区颐和园路5号金光生命科学大楼