北京大学生命科学学院
2012学年秋季学期系列学术讲座之五
题目：A personal history of Structural Biology
报告人：Michael G. Rossmann
Hanley Distinguished Professor, Department of Biological Sciences, Purdue University
时间：2012年10月19日（周五），13:00-14:30 PM
地点：理教211
The central interest of Rossmann`s laboratory is the determination of the three-dimensional, atomic resolution structure of viruses. However, it is not only the structure of the mature infectious virus that interests us, but all the structures that are involved in the assembly of the virus in a host cell, the interaction of viruses with host cells that initiates entry into the cell and infection, as well as the structures of viruses complexed with neutralizing antibodies or antiviral agents (potential drugs). In short, they are investigating the way viruses interact with their environment.
Their tools are X-ray crystallography for high resolution studies and electron microscopy for lower resolution studies of transient virus complexes, as well as all the tools of molecular biology. The viruses they are currently studying include a variety of small RNA animal viruses, such as common cold viruses, polioviruses and coxsackieviruses. They are also looking at more complicated, lipid membrane enveloped RNA viruses, such as dengue virus and alphaviruses. They have long been interested in the small DNA parvoviruses. Finally, they have been studying how viruses package their nucleic acid genomes in the analyses of a variety of bacterial viruses.
联系人：郑晓峰（电话：62755712）
欢迎各位老师和同学积极参加！