报告题目：The JAK-STAT Pathway: History and Now: A New Conecept of PERI-GENETICS in Stem Cells, Genome Integrity, Cancer and Immunity

报告人：Xin-Yuan Fu

Cancer Science Institute (CSI), Singapore

Department of Biochemistry; Yong Loo Lin School of Medicine,

National University of Singapore

报告时间：11月28日上午10：30到11：30

报告地点：综合科研楼302会议室

联系人：汤富酬，电话：62744062

Abstract：

The first two STAT proteins were discovered over 24 years ago as transcription factors of p91 (STAT1) and p113 (STAT2) activated by interferon-alpha 1. The molecular cloning of genes encoding for p91 and p113 revealed the STAT gene family 2. Finding a SH2 domain in each of STAT proteins indicated STAT proteins are not only transcription factors but also serve as signal transducers 3. Now we propose that STAT proteins are regulators of epigenetic modeling of the genome. Thus, this integrated and regulatory process from signals to specific epigenetic modeling of genome and to eventual gene transcription is termed as “Peri-Genetics". We present evidence that STAT proteins regulate epigenetic events. I will further present our findings on Critical roles of STATs embryogenesis 4, Cancer and immunity.

1. Fu, X. Y., Kessler, D. S., Veals, S. A., Levy, D. E. & Darnell, J. E., Jr. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. PNAS 87, 8555-8559 (1990).

2. Fu, X. Y., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E., Jr. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. PNAS 89, 7840-7843 (1992).

3. Fu, X. Y. A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Cell 70, 323-335 (1992).

4. Dang Vinh Do, Jun Ueda, C Lorthongpanich, Wenjun Zhang , Akira Moh , Yi Zhou, Bo Feng, Guoji Guo, Peiyu J Lin, Md Zakir Hossain, Daniel M. Messerschmidt , Qiang Wu, Paul Robson, Huck Hui Ng, Lorenz Poellinger, Barbara B. Knowles, Davor Solter and Xin-Yuan Fu (2013) A Genetic and Developmental Pathway from STAT3 to the OCT4-NANOG Circuit Essential for Maintenance of ICM Lineages in vivo. Genes & Development, 27(12):1378-90. PMID: 23788624