主讲人：Yifan Cheng

讲座地点：新生物楼101报告厅

讲座日期：2014-04-14

 

学术报告
题目：Structure determination of integral membrane protein by single particle cryo-EM
报告人：Yifan Cheng
The Keck Advanced Microscopy Laboratory,
Department of Biochemistry and Biophysics
University of California, San Francisco
时间：2014年4月14日（周一）下午13:00-15:00 PM
地点：新生物楼101报告厅
As a versatile tool in structural biology, single particle electron cryo-microscopy (cryo-EM) has achieved milestones of determining near atomic resolution three-dimensional (3D) reconstructions of non-enveloped viruses with icosahedral symmetry. Recent technological breakthroughs in single particle cryo-EM, particularly the development of MOS based direct electron detection camera and robust algorithms for correction of motion induced image blurring are transformative, and enabled near atomic resolution structure determination of a broad range of proteins without crystals. Using these novel single particle cryo-EM technologies, we determined the atomic structure of a mammalian Transient Receptor Potential (TRP) ion channel, TRPV1, to crystallographic resolution without crystals.
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