主讲人：Andrew A. Pieper

讲座地点：北京大学新生物楼101报告厅

讲座日期：2013-10-28

联系人：方敏 （6276-8106）

 

生命科学联合中心学术报告
题目：Discovery and Characterization of the P7C3-Class of Neuroprotective Molecules.
报告人：ANDREW A. PIEPER, MD, PhD
Associate Professor, Department of Psychiatry
Director of Translational Neuroscience
University of Iowa Carver College of Medicine, Iowa City, IA
时间：2013-10-28（周一），13:00-14:00pm
地点：北京大学新生物楼邓佑才报告厅
联系人：生命科学联合中心，方敏 （6276-8106）
There are currently no drugs available that block neuronal cell death in any of the wide variety of neurodegenerative diseases. Through an in vivo screening approach, we have discovered the ‘P7C3-class’ of neuroprotective aminopropyl carbazoles. These molecules stabilize mitochondria and block neuronal cell death in multiple models of neurodegeneration, including Parkinson`s disease, amyotrophic lateral sclerosis, traumatic brain injury and peripheral nerve injury. Thus far, our agents appear devoid of any signs of toxicity, despite prolonged administration and diligent pre-clinical pharmacology. We are optimizing the P7C3-class of molecules for potency and efficacy, while addressing known or perceived chemical liabilities. Our hope is that these efforts will lead to development of a drug to treat neurodegenerative disease.
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