主讲人：郑勇 博士

讲座地点：一教308室

讲座日期：2013-09-25

联系人：纪建国

 

学术报告
题目：Signaling in time and space: scaffold protein-medicated dynamic probing of EGFR signaling networks
报告人：郑勇 博士
加拿大多伦多大学
时间：2013年9月25日（周三）18:30-20:30
地点：一教308室
Dr Zheng interested in developing and applying novel proteomic methods to measure cell signaling under normal and pathological conditions at a global level. Especially, he designed and developed an integrative approach that combine quantitative mass spectrometry method with genetic and chemical methods to illustrate in great details how cellular signaling networks, such as receptor tyrosine kinase-mediated networks, are dynamically regulated in time and space.
1. Zheng Y, Zhang C, Croucher DR, Soliman MA, St‐Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Cowill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Regulation of protein signaling networks by the scaffold protein Shc1 in time and space. Nature, 2013, 499(7457):166-71. Article.
2. Zheng Y, Liu HZ, Coughlin J, Zheng J, Li L, Stone JC. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood, 2005, 105(9):3648-54.
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