北京大学 | ENGLISH
讲座信息
Decoding Regulatory Mechanisms of Hematopoiesis
日期: 2018-11-12       点击量: 1343
时间:2018年12月27日(星期四)13:00-14:00
地点:金光生命科学大楼411
讲座人:Xin Liu, Ph.D.
Postdoctoral research fellow, University of Texas Southwestern Medical Center

题目:Decoding Regulatory Mechanisms of Hematopoiesis

摘要:Hematopoiesis requires highly coordinated gene expression through transcriptional and post-transcriptional mechanisms. By comparing enhancer landscape, transcriptional factor occupancy, 3D chromatin structure and transcriptomic changes during blood cell differentiation, I identified lineage-specific enhancers and macro-molecular interactions driving enhancer activation, providing initial insights into enhancer dynamics and gene expression programs directing lineage-specific transcription during hematopoiesis. Further comparison between the proteomic and transcriptomic changes in erythroid development uncovered post-transcriptional pathways leading to enhanced mitochondrial biogenesis. Perturbation of mitochondria interrupted intracellular metabolism, leading to altered transcriptional regulation and defective lineage differentiation, which provide a new pathway between mitochondrial biogenesis and epigenetic gene regulation indispensable for normal erythropoiesis.


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